ScienCell Research Laboratories

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ScienCell Research Laboratories is a private organization in the life sciences field, with the mission to acquire, culture, quality test, and distribute materials related to cell biology for experimental and therapeutic use. It was established in December 1999 as Sciencell Research Laboratories by James Shen, and then incorporated in 2007. ScienCell serves as a worldwide bank for normal primary human and animal cells, common and specialty cell culturing media, and related reagents. Recently, the organization introduced media for stem cells and assays for gene expression profiling to the research community. ScienCell Research Laboratories is the first company in the world to freeze neurons for research use.


Human Hippocampal Neurons Immunostained for nuclei (blue), beta-III tubulin (red) and F-actin (green).

While pursuing his graduate and postdoctoral studies in neuroscience, Dr. James Shen devoted large amounts of time to culturing neural and glial cells for his research. He realized that a commercial source of cells would facilitate his work, as well as the general study of human brain-derived neural stem cells, neurons, astrocytes, oligodendrocytes, and microglia. However, there were none were available. To address this need, he founded ScienCell in 1999, the first company of its kind that cultured human brain cells on a commercial level. To stimulate neuroscience research, the company offered academic scientists free human neural stem cells. Shen later expanded his cultures to primary cells from all organs of the human body. ScienCell has since become a main supplier of human and animal primary cells worldwide. The company moved from San Diego to Carlsbad, California, and was incorporated in 2007.

Research materials

ScienCell Research Laboratories provides researchers with over 260 types of normal primary cells from 24 human and animal systems including nervous, cardiac, hepatic, renal, gastrointestinal, pulmonary, adipose, dermal, oral, ocular, hair, lymphatic, skeletal, urethral, male reproductive, female reproductive, umbilical, and placental. The primary cells are isolated and purified using methods proprietary to ScienCell and are cryopreserved at early passage to maintain primary cell functionality. ScienCell serves the life science community by categorizing human and animals primary cells, cell culture media, and cell culture reagents and assays. Additionally, scientists at ScienCell are working to educate the scientific research community about the complexities of working with primary cells.[1]


Front View of Sciencell

ScienCell administration and production facilities are based in Carlsbad, California. This includes the laboratory and the biological repository that houses more than 20 freezers to store biomaterials, including vapor-phase liquid nitrogen freezers, mechanical freezers, and cold rooms for storage at 4 °C. The community of users of Sciencell products and services is international, and includes researchers in academia and government, as well as private industry. Over 70% of ScienCell’s 20,000+ customer base represents academia and industry in United States– 50% from universities and colleges and 35% from private industry. Government customers comprise 10-15% of the organization’s total, including the US ARMY;[2][3] The remaining 30% are international customers. ScienCell deals with authorized distributors in Africa, Australia, Belgium, China, Denmark, Dubai, France, Germany, India, Indonesia, and Israel and makes other international shipments directly from its California facilities. ScienCell is also cited in various peer-reviewed publications that use its products in journals such as the US National Library of Medicine National Institutes of Health (PubMed), International Journal of Biological Sciences , the Public Library of Science (PLOS), and others.

Annual Meetings

ScienCell Research Laboratories, Inc.[4] attends and exhibits every year at the American Society for Cell Biology annual meeting,[5] Society for Experimental Biology,[6] American Association for Cancer Research annual meeting,[7][8] Society of Neuroscience,[9] also including International Society for Stem Cell Research[10] to connect and network with teachers, professors and other professional research scientist to encourage future discovery and collaboration.


ScienCell Research Laboratories collaborates with companies around the world to distribute their materials and help the research community globally, Viz. Cosmo Bio[11] from Japan, CliniSciences[12] from France, Provitro[13] located in Germany, Caltag Medsystems[14] located in United Kingdoms, 3HBiomedical[15] in Sweden, Hansaem Biotech[16] from Korea, and several distributors in China.[17][18][19]


Cryopreservation with ScienCell cell freezing media has been tested[20] by Thermo Fisher Scientific and yielded great results as compared to Sigma-Aldrich, Lonza, Merck Millipore and BioLife. As a research company, ScienCell has developed unique media and reagents to promote pluripotent stem cell growth and differentiation; and coauthored book "Human Stem Cell Manual: A Laboratory Guide"[21] by Academic publishing.Besides these ScienCell have contributed to several Research papers in collaboration with other researchers in National Institutes of Health repository, like Addiction (journal),[22] the Public Library of Science (PLOS),[23] Journal of Molecular and Cellular Cardiology (J. Mol. Cell. Cardiol.),[24] Journal of Cell Transplantation.[25]


  1. Welser-Alves, Jennifer (30 October 2015). "The Advantages and Difficulties of Working with Primary Cells - ASCB". Retrieved October 30, 2015. 
  2. Semlali, A; Leung, KP; Curt, S; Rouabhia, M (May 2011). "Antimicrobial decapeptide KSL-W attenuates Candida albicans virulence by modulating its effects on Toll-like receptor, human β-defensin, and cytokine expression by engineered human oral mucosa.". Peptides 32 (5): 859–67. PMID 21291939. 
  3. Antimicrobial decapeptide KSL-W attenuates Candida albicansvirulence by modulating its effects on Toll-like receptor, human β-defensin, and cytokine expression by engineered human oral mucosa Semlali, A; Leung, KP; Curt, S; Rouabhia, M (May 2011).
  4. "Sciencell Research Laboratories Inc: Company Profile". 
  5. "PDF file". 
  6. "Workshop at Experimental Biology Annual Meeting". 
  7. "2011 Annual Meeting Exhibitors - ASCB". 12 January 2012. 
  8. "The American Association for Cancer Research Annual Meeting Exhibitors list". Retrieved 16 September 2014. 
  9. "Society of Neuroscience Exhibitors list". 
  10. "2013 Exhibit Information International Society for Stem Cell Research". 
  11. "ScienCell Research Laboratories社 正常初代培養細胞(ヒト) | コスモ・バイオ株式会社". 
  12. "Clinisciences". 
  13. "provitro". 
  14. 770848, Caltag Medsystems. "Sciencell cell and cell-related experimental and therapeutical products distributed by Caltag Medsystems Ltd". 
  15. "3H Biomedical: More Innovation, Less Preparation". 
  17. "首 页 — 北京裕恒丰科技有限公司". 
  18. "中乔新舟--首页". 
  19. "首页_达科为生物技术有限公司". 
  20. Scientific, ThermoFisher. "Comparative analysis of Recovery Cell Culture Freezing Medium vs. currently available cryopreservation technologies.". 
  21. Peterson, Suzanne; Loring, Jeanne F. (in en). Human Stem Cell Manual: A Laboratory Guide. Academic Press. ISBN 9780123854742. 
  22. Lee, Chun-Ting; Lehrmann, Elin; Hayashi, Teruo; Amable, Rose; Tsai, Shang-Yi; Chen, Jia; Sanchez, Joseph F.; Shen, James et al. (December 2009). "Gene Expression Profiling Reveals Distinct Cocaine-Responsive Genes in Human Fetal CNS Cell Types". Journal of Addiction Medicine 3 (4): 218–226. Template:Citation error. 
  23. Lee, Chun-Ting; Chen, Jia; Hayashi, Teruo; Tsai, Shang-Yi; Sanchez, Joseph F; Errico, Stacie L; Amable, Rose; Su, Tsung-Ping et al. (10 June 2008). "A Mechanism for the Inhibition of Neural Progenitor Cell Proliferation by Cocaine". PLoS Medicine 5 (6): e117. Template:Citation error. 
  24. LI, S; LI, Q; SHEN, J; DONG, F; SIGMON, V; LIU, Y; REN, J (February 2006). "Attenuation of acetaldehyde-induced cell injury by overexpression of aldehyde dehydrogenase-2 (ALDH2) transgene in human cardiac myocytes: role of MAP kinase signaling". Journal of Molecular and Cellular Cardiology 40 (2): 283–294. Template:Citation error. 
  25. Yang, M; Donaldson, AE; Marshall, CE; Shen, J; Iacovitti, L (2004). "Studies on the differentiation of dopaminergic traits in human neural progenitor cells in vitro and in vivo.". Cell transplantation 13 (5): 535–47. PMID 15565866. 

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