Tyler Alexander Allen

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Scientist

Tyler Alexander Allen (born March 6, 1992) is an American cellular biologist at North Carolina State University College of Veterinary Medicine. He is best known for his involvement in the discovery and characterization of the cell extravasation mechanism known as angiopellosis. Angiopellosis represents a fundamental process for how cells that are not native to the circulation exit once in the blood. This discovery led to a better understanding of how therapeutic cells exit the circulation when injected or infused into the blood. Allen is a graduate of North Carolina State University, where he received a Bachelor's in Biology.

Biography

Allen was born in Houston, TX, the last of three children to Craig Allen, and his wife Alveda Allen. In 2005, Allen, along with his family, moved to North Carolina where he attended Northern High School (Durham, NC) for his freshman and sophomore years, before attending and graduating from Middle College High School (Durham, NC).

Allen received two B.S. degrees from North Carolina State University; one in Biology, the other in Plant Biology in 2014. As an undergraduate, Allen conducted oncology research under the guidance of cancer expert Dr Jonathan Horowitz (NCSU), where he studied the interface of two cancer-related proteins. His undergraduate thesis was titled: Loss of p53 Increases Post-Natal Survival of SP2 Transgenic Mice.

In 2014, Allen began his PhD[1] studies in Comparative Biomedical Sciences, at the NCSU College of Veterinary Medicine. As a PhD student, he successfully characterized the method of extravasation non-leukocytic cells employ to exit circulation, termed angiopellosis. Allen currently serves as the President of the Graduate Student Association at NCSU for the 2016-17 term.[2]

Allen is also known for the topic of his TEDx talk where he discusses the power of positivity and necessity of negativity in life. He talks about how negativity can challenge individuals in unique ways, possible even resulting in long-term positivity and how one's standard of living is dependent on how one chooses to interpret positive and negative experiences.[3]

Research

Allen's research involves the study of how cells migrate through circulation and exit blood vessels. Through his research, the characterization of how therapeutic stem cells reach damaged tissue when injected into the blood was achieved.[4] This was termed angiopellosis, and represents an alternative mechanism of cell extravasation. Allen uses transgenic zebrafish as a model for humans disease pathways. Using genetic manipulation, Allen utilized a strain of zebrafish in which the blood vessels express green fluorescent protein (gfp). This strain allowed Allen to observe, in real-time, the exact mechanism cells used to exit blood vessels when injected intravenously.

Allen has also been involved in the creation of a novel method to produce regenerative lung cells for therapeutic lung regeneration.[5] Additionally he was involved in the creation of a way to rapidly and efficiently produce coronary artery ligation and myocardial infarction in mice.[6]

Allen's ongoing research involved the study of how cancer/tumor cells utilize angiopellosis to metastasize and form secondary tumors.[7]

References

  1. "Tyler Allen | NC State Veterinary Medicine". https://cvm.ncsu.edu/directory/allen-tyler/. 
  2. "People  :: Graduate Student Association". https://gsa.ncsu.edu/about/people/. 
  3. TEDx Talks (2015-05-04), The Power of Positivity, and the Necessity of Negativity | Tyler Allen | TEDxNCSU, https://www.youtube.com/watch?v=IdiLc1U18UA, retrieved 2016-10-22 
  4. Allen, Tyler A.; Gracieux, David; Talib, Maliha; Tokarz, Debra A.; Hensley, M. Taylor; Cores, Jhon; Vandergriff, Adam; Tang, Junnan et al. (2016-07-01). "Angiopellosis as an Alternative Mechanism of Cell Extravasation" (in en). STEM CELLS: n/a–n/a. Template:Citation error. ISSN 1549-4918. http://onlinelibrary.wiley.com/doi/10.1002/stem.2451/abstract. 
  5. Henry, Eric; Cores, Jhon; Hensley, M. Taylor; Anthony, Shirena; Vandergriff, Adam; Andrade, James B. M. de; Allen, Tyler; Caranasos, Thomas G. et al. (2015-09-10). "Adult Lung Spheroid Cells Contain Progenitor Cells and Mediate Regeneration in Rodents With Bleomycin-Induced Pulmonary Fibrosis" (in en). Stem Cells Translational Medicine: sctm.2015–0062. Template:Citation error. ISSN 2157-6564. PMC 4622409. PMID 26359426. http://stemcellstm.alphamedpress.org/content/early/2015/09/09/sctm.2015-0062. 
  6. Andrade, James N. B. M. de; Tang, Junnan; Hensley, Michael Taylor; Vandergriff, Adam; Cores, Jhon; Henry, Eric; Allen, Tyler A.; Caranasos, Thomas George et al. (2015-11-24). "Rapid and Efficient Production of Coronary Artery Ligation and Myocardial Infarction in Mice Using Surgical Clips". PLOS ONE 10 (11): e0143221. Template:Citation error. ISSN 1932-6203. PMC 4658059. PMID 26599500. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0143221. 
  7. NCState (2016-07-29), Dangerous Moves (1st place - 2016), https://www.youtube.com/watch?v=Qlz91vaTzhU, retrieved 2016-10-22 

External links